RAPID INFORMATIVE SCREENING OF NANO-ALAPTIDE AS POTENTIAL TRANSDERMAL PERMEATION ENHANCER OF ACETYLSALICYLIC ACID AND PARACETAMOL
نویسندگان
چکیده
منابع مشابه
Rapid Screening of Mupirocin Skin Permeation Modification by Micronized and Nanonized Alaptide
The investigation deals with the affection of permeation of mupirocin from the Bactroban® Leciva ointment through full-thickness pig ear skin by alaptide that was applied in micronized or nanonized form as a potential excipient. Alaptide, (S)-8-methyl-6,9-diazaspiro[4.5]decan-7,10-dione, was the original Czech compound. It was discovered that micronized alaptide significantly enhanced the perme...
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The investigation deals with the influence of permeation of rutin from carboxymethyl cellulose gel through full-thickness pig ear skin by (S)and (R)-alaptide as potential excipients. Alaptide, 8-methyl-6,9diazaspiro[4.5]decan-7,10-dione, is the original Czech compound. By means of this rapid screening it was found out that the permeation of rutin through the skin increased linearly with time an...
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Transdermal drug delivery (TDD) is used to deliver drugs through the skin as an alternative to oral, intravascular, and subcutaneous routes. While there are many advantages to TDD, skin is a very effective barrier and provides resistance to drug delivery. To improve drug delivery through the skin, permeation enhancers are used. We developed an axisymmetric COMSOL Multiphysics model of drug diff...
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The objective of our present work was to prepare transdermal matrix patches containing the drug, diclofenac diethylamine with various polymeric combinations of polyvinylpyrrolidone and ethylcellulose and to study the mechanism of release of the drug from the patches and its skin permeation. Sorbitan monolaurate 20 (Span 20), a non-ionic surfactant was added to the concentrations (0.1% wt/vol), ...
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ژورنال
عنوان ژورنال: Military Medical Science Letters
سال: 2014
ISSN: 0372-7025,0372-7025
DOI: 10.31482/mmsl.2014.006